Futoshi Higa Selected Research

Legionnaires' Disease (Legionnaire's Disease)

6/2010	Phospholipase PlaB is a new virulence factor of Legionella pneumophila.
1/2010	Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells.
5/2008	Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone.
1/2008	Clinical features of two cases of Legionnaires' disease with persistence of Legionella urinary antigen excretion.
6/2005	Efficacy of pazufloxacin mesilate in Legionnaires' disease: a case report and in vitro study of the isolate.
12/2003	In vitro and in vivo activity of olamufloxacin (HSR-903) against Legionella spp.

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Futoshi Higa Research Topics

Disease

20	Pneumonia (Pneumonitis) 02/2021 - 02/2002
17	Infections 05/2020 - 02/2002
7	Tuberculosis (Tuberculoses) 10/2020 - 05/2003
6	Fever (Fevers) 10/2020 - 11/2002
6	Communicable Diseases (Infectious Diseases) 09/2019 - 04/2005
6	Legionnaires' Disease (Legionnaire's Disease) 06/2010 - 12/2003
5	Cough 10/2020 - 11/2002
5	Human Influenza (Influenza) 01/2016 - 09/2009
3	Immune Reconstitution Inflammatory Syndrome 10/2020 - 01/2010
3	Pulmonary Tuberculosis 01/2020 - 05/2003
3	Acquired Immunodeficiency Syndrome (AIDS) 01/2014 - 01/2010
3	Necrosis 11/2013 - 02/2002
3	Granuloma 12/2012 - 01/2012
2	Pleural Effusion (Pleural Effusions) 10/2020 - 12/2007
2	Lung Diseases (Lung Disease) 07/2017 - 01/2012
2	Chronic Kidney Failure (Chronic Renal Failure) 07/2017 - 01/2009
2	Falciparum Malaria (Plasmodium falciparum Malaria) 01/2015 - 07/2002
2	Malaria 01/2015 - 07/2002
2	Acute Lung Injury 05/2014 - 03/2011
2	Leukocytosis (Pleocytosis) 01/2012 - 01/2007
2	Pneumocystis Pneumonia (Pneumocystis carinii Pneumonia) 05/2011 - 01/2009
2	HIV Infections (HIV Infection) 05/2011 - 01/2009
2	Disease Progression 06/2009 - 04/2008
2	Legionellosis 01/2008 - 06/2005
1	Pulmonary Sarcoidosis 12/2020
1	Sarcoidosis (Schaumann Disease) 12/2020
1	Crohn Disease (Crohn's Disease) 10/2020
1	Dyspnea (Shortness of Breath) 06/2019
1	Dehydration (Water Stress) 01/2019
1	Malnutrition (Nutritional Deficiencies) 01/2019
1	Hypotension (Low Blood Pressure) 01/2019
1	Liver Diseases (Liver Disease) 01/2019
1	Thrombocytopenia (Thrombopenia) 11/2017
1	Hyponatremia 11/2017
1	Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) 10/2017
1	Diabetes Mellitus 10/2017
1	Mycobacterium avium-intracellulare Infection 10/2017
1	Heart Failure 07/2017
1	Osteomyelitis 01/2016
1	Bacteremia 01/2016
1	Adenocarcinoma of Lung 01/2015
1	Small Cell Carcinoma 01/2015
1	Respiratory Insufficiency (Respiratory Failure) 09/2014
1	Anemia 01/2014
1	Pure Red-Cell Aplasia 01/2014

Drug/Important Bio-Agent (IBA)

16	AntigensIBA 02/2021 - 07/2002
7	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2020 - 11/2002
6	C-Reactive ProteinIBA 06/2019 - 01/2007
5	Pharmaceutical PreparationsIBA 01/2016 - 02/2002
4	AcidsIBA 10/2020 - 08/2009
3	Anti-Bacterial Agents (Antibiotics)IBA 06/2019 - 12/2013
3	Proteins (Proteins, Gene)FDA Link 05/2014 - 05/2003
3	Prednisolone (Predate)FDA LinkGeneric 05/2008 - 06/2002
2	SteroidsIBA 10/2020 - 05/2011
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2020 - 03/2007
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2009
2	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 06/2019 - 11/2017
2	MacrolidesIBA 10/2016 - 01/2009
2	Azithromycin (Zithromax)FDA LinkGeneric 01/2015 - 01/2009
2	Ampicillin (Omnipen)FDA LinkGeneric 12/2013 - 02/2002
2	Messenger RNA (mRNA)IBA 01/2013 - 11/2007
2	DNA (Deoxyribonucleic Acid)IBA 12/2012 - 06/2002
2	Neuraminidase (Sialidase)IBA 07/2012 - 01/2012
2	polyglucosanIBA 05/2011 - 01/2009
2	Interleukin-8 (Interleukin 8)IBA 01/2010 - 11/2007
2	NF-kappa B (NF-kB)IBA 01/2010 - 11/2007
2	FlagellinIBA 01/2010 - 11/2007
2	Rifampin (Rifampicin)FDA LinkGeneric 08/2009 - 01/2007
2	Levofloxacin (Levaquin)FDA Link 06/2009 - 12/2003
2	CaspasesIBA 05/2008 - 02/2002
2	Erythromycin (Erycette)FDA LinkGeneric 01/2007 - 12/2003
2	Ciprofloxacin (Cipro)FDA LinkGeneric 01/2007 - 11/2002
2	FluoroquinolonesIBA 06/2005 - 11/2002
2	Anti-Infective Agents (Microbicides)IBA 04/2005 - 08/2004
1	Infliximab (Remicade)FDA Link 10/2020
1	PeriostinIBA 01/2020
1	Matrix Metalloproteinases (MMPs)IBA 01/2020
1	Interferon-gamma (Interferon, gamma)IBA 01/2020
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2018
1	Transaminases (Aminotransferases)IBA 01/2018
1	Alanine (L-Alanine)FDA Link 01/2018
1	Aspartic Acid (Aspartate)FDA Link 01/2018
1	QuinolonesIBA 11/2017
1	Clarithromycin (Biaxin)FDA LinkGeneric 11/2017
1	beta-LactamsIBA 10/2016
1	TeicoplaninIBA 01/2016
1	Interleukin-17 (Interleukin 17)IBA 01/2015
1	Tyrosine Kinase InhibitorsIBA 01/2015
1	Erlotinib Hydrochloride (CP 358,774)FDA Link 01/2015
1	ErbB Receptors (EGF Receptor)IBA 01/2015
1	InterferonsIBA 05/2014
1	Lamivudine (Epivir)FDA Link 01/2014
1	Zidovudine (Retrovir)FDA LinkGeneric 01/2014

Therapy/Procedure

15	Therapeutics 12/2020 - 08/2004
6	Drug Therapy (Chemotherapy) 05/2020 - 01/2007
2	Highly Active Antiretroviral Therapy (HAART) 01/2011 - 01/2010
2	X-Ray Film 12/2007 - 05/2003
1	Long-Term Care 01/2018
1	Length of Stay 07/2017
1	Cannula 09/2014